[转帖]冠心病和阻塞性睡眠呼吸暂停低通气的相关系

阻塞性睡眠呼吸暂停低通气综合征(OSAHS)在医学界的临床应用中是最为常见的一种呼吸症状，病人主要表现为睡眠打鼾并伴有呼吸暂停和呼吸表浅，夜间反复发生低氧血症、高碳酸血症和睡眠结构紊乱，导致白天嗜睡、心脑血管病并发症乃至多脏器损害，严重影响患者的生活质量和寿命。

Obstructive sleep apnea hypopnea syndrome (OSAHS) the most common clinically, mainly as sleep apnea and snoring accompanied by shallow breathing, recurrent nocturnal hypoxemia, hypercapnia and sleep disordered structure, leading to daytime drowsiness, cardiovascular and cerebrovascular disease complications and even multiple organ damage, seriously affecting the quality of life of patients and the life.

中华结核和呼吸杂志三月第三期刊登一项研究，研究者以2005年3至12月南京医科大学第一附属医院心脏科连续收治的82例患者为研究对象，依据多导睡眠仪监测得出的睡眠呼吸暂停低通气指数（AHI）分为轻度OSAHS组（5〈AHI〈20，38例）、中重度OSAHS组（AHI〉20，20例）和非OSAHS组（对照组，AHI〈5，24例）。3组均进行冠状动脉造影及Gensim评分，呼吸机后者用于评估冠状动脉粥样硬化病变的程度。进一步探讨阻塞性睡眠呼吸暂停低通气综合征（OSAHS）与冠心病以及冠状动脉粥样硬化的相关性。

Chinese Journal of Tuberculosis and Respiratory Diseases published a study on March third, researchers in March to December 2005 the First Affiliated Hospital of Nanjing Medical University, Cardiology, 82 consecutive patients were admitted to study, based on polysomnography monitoring have out of the sleep apnea-hypopnea index (AHI) were divided into mild OSAHS group (5 <AHI <20,38 cases), moderate and severe OSAHS group (AHI> 20,20 cases) and non-OSAHS group (control group, AHI < 5,24 patients). Group 3 underwent coronary angiography and Gensim score, which is used to assess coronary artery atherosclerosis extent. Further study of obstructive sleep apnea hypopnea syndrome (OSAHS) and coronary heart disease and coronary sclerosis.

江苏省老年医院江苏省老年医学研究所呼吸科陆甘等研究人员研究显示，轻度和中重度OSAHS组AHI的中位数（10.9和29.3R/h）显著高于对照组（2.9R/h），最低血氧饱和度[（84±9）%和（81±9）%]显著低于对照组[（89±6）%]；冠心病发病率[66%（25/38）和95%（19/20）]显著高于对照组[29%（7/24）]；冠状动脉病变单支受累百分率[24%（9/38）和20%（4/20）]显著高于对照组[17%（4/24）]，多支受累百分率[42%（16/38）和80%（16/20）]显著高于对照组[12.5%（3/24）]；中重度OSAHS组的Gensim评分中位数（35.0）显著高于对照组（1.0），AHI与Gemini评分呈显著正相关。

Geriatric Hospital, Jiangsu Province, Jiangsu Province, Institute of Geriatrics, Respiratory Lu Gan and other researchers showed mild to severe OSAHS group and the median AHI (10.9 and 29.3R / h) was significantly higher (2.9R/h), minimum oxygen saturation [(84 ± 9)% and (81 ± 9)%] was significantly lower than the control group [(89 ± 6)%]; coronary heart disease incidence [66% (25 / 38) and 95% (19/20)] was significantly higher than [29% (7 / 24)]; percentage of coronary artery single vessel involvement [24% (9 / 38) and 20% (4 / 20)] significantly higher than [17% (4 / 24)], the percentage of multi-branch involvement [42% (16/38) and 80% (16/20)] was significantly higher [12.5% (3 / 24 )]; in severe OSAHS group Gensim median score (35.0) was significantly higher (1.0), AHI and Gemini score was significantly positively correlated.

因此可见OSAHS可能是导致冠状动脉粥样硬化和冠心病的一个重要的独立危险因素，建议将其列入冠心病的二级预防。

This shows OSAHS may lead to coronary atherosclerosis and coronary heart disease is an important independent risk factors recommend its inclusion in secondary prevention of coronary heart disease.

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