Roche cobas 4000（C311+E411）系列

Freedom to realize your lab’s potential

The cobas 4000 analyzer series include the cobas c 311 module for clinical chemistry and the cobas e 411 module for immunoassays. The combination of the two analyzers with the cobas IT 3000 solution for managing sample workflow provides true operational integration for small laboratories.

cobas c 311 analyzer

A passion for predictability in chemistry

• The cobas c packs deliver maximum handling convenience with minimum reagent waste, liquid ready-to-use reagents and 90-day average onboard reagent stability
• With industry-leading parameters such as Tina-quant? HbA1c with automated pre-treatment of whole blood samples, the cobas c 311 analyzer offers the broadest assay menu on the market
• Roche/Hitachi in design and manufacture, the cobas c 311 analyzer continues our long tradition of proven reliability

cobas e 411 analyzer

Peace of mind in immunology -

• The cobas e packs offer best-in-class handling convenience and reagent efficiencies for immunochemistry testing with liquid ready-to-use reagents and 60-day average onboard reagent stability
• 9-minute STAT applications for troponin, CK-MB, myoglobin, hCG and PTH provide unmatched response times
• At the heart of the cobas e 411 analyzer, ECL technology delivers the unique combination of high analytical sensitivity, wide measuring ranges and 9 minute STAT applications for unparalleled performance in immunochemistry

Work area management solutions

Standardized and integrated data management

• Reducing variability through consistency in decision management
• Increased efficiency using comprehensive workflow tools
• Active management of results and patient data providing optimal information management for physicians

cobas? e-services

Lab intelligence at your fingertips

• cobas e-support – immediate troubleshooting via remote access improving system uptime and operational efficiency
• cobas e-library – automatic update functionality safeguarding online access to most recent application information on reagents, calibrators and controls
• cobas link – enabling cobas e-services via secure gateway connection between laboratory and Roche

* in preparation

 

cobas c 311 analyzer

System	Fully automated, random access analyzer for Clinical Chemistry, Electrolytes & Homogeneous Immunoassays (HIA)
Test Throughput	Up to 300 tests/hr (photometry), 450 tests/hr (ISE only) and 300 tests/hr (mixed)
Reagent concept	Barcoded cobas c reagent packs with convenient packaging & ready-to-use reagents
Onboard reagent capacity	Up to 45 assays (42 cooled cassette slots + 3 channels for ISE)
Programmable parameters	Up to 117 photometric, 3 ISE tests, 8 calculated parameters & 3 serum indices
Sample types	Serum, plasma, urine, CSF & whole blood
Onboard sample capacity	108 positions with continuous access & STAT interrupt capability
Sample container types	Primary tubes: 5 – 10 mL (16x100, 16x75, 13x100, 13x75 mm) Sample cup: 2.5 mL Micro cup: 1.5 mL Cup on tube
Sample volume	1.0 to 35 μL in 0.1 μL steps
Sample clot detection	Yes
Minimum sample volume	Primary tubes: 700 μL Sample cup: 100 μL Micro cup: 50 μL
Sample barcode types	Code 128, Codabar (NW 7), Interleaved 2 of 5, Code 39
System interfaces	Touchscreen PC, RS 232 serial interface, bi-directional, cobas link (TeleService and auto download)
Sample database	10,000 routine/STAT samples
Test methods	1 point, 1 point + prozone check, 2 point, 2 point kinetic, 2 point + prozone check, 3 point, 1 point + kinetics, Rate A, Rate A + serum index, Rate A with blank, Rate B
Calibration methods	Linear, non-linear multi-points, 2 point calibration, K-factor, up to 100 calibrators pre-programmable, storage of up to 180 curves; Preventive calibration of stand-by cassettes.
QC methods	Real-time, individual & cumulative QC; Auto QC; Up to 100 different controls pre-programmable; Preventive QC after calibration of stand-by cassettes
Rerun/repeat/reflex	Automatic rerun/manual reruns, repeats & automatic reflex supported
Electrical requirements	Power requirements: 230/400 Volts AC 3/N/PE, 110 Volts AC 1.5 kVA Frequency: 50 Hz or 60 Hz +/– 0.5 %
Water/waste requirements	Water quality: Bacteria free, de-ionised water supply resistance of 1.0 μS/cm max. Water consumption: Up to 12 L/hr during operation Water pressure: 0.5 – 3.5 kg/cm3 (49 – 343 KPa) Water temperature: 15 to 30°C Biohazards waste: Separate container located in the system Wall drain for waste: 100 mm above the floor
Regulatory compliance	GS, CE, UL, C-UL compliant
Operating conditions	Ambient temperature/humidity: 15 to 32°C/30 to 85% (RH, without condensation) Heat & noise output: 2 kcal/h; < 65 dB
Physical dimensions	Width: 134 cm Depth: 86 cm Height: 126 cm Weight: 270 kg

 

cobas e 411 analyzer

System	Fully automated, continuous loading and random access system for immunoassay analysis based on ECL technology. Available as a disk and rack system. System components: Analytical module including touchscreen PC
Test Throughput	Up to 86 tests/hr
Reagent concept	cobas e reagent pack: Ready-to-use reagents Onboard reagent capacity: 18 channels/reagent slots for up to 18 different assays Evaporation protection: Automatic closure of reagent lids
Programmable parameters	Max 60 assays definable via 2D-barcode including all necessary information (programming by loading)
Sample types	Serum, Plasma, Urine and others
Onboard sample capacity	Load/unload capacity: Disk: 30 samples Rack: 75 samples on 15 RD standard 5 position rack Rack types: Routine, STAT, Control, Calibrator STAT handling: Disk: Any unoccupied position on the sample disk Rack: Dedicated STAT port on rack feeder
Sample container types	Primary tubes: 5–10 mL; 16x100, 16x75, 13x100, 13x75 mm Sample cup: 2.5 mL Cups on tube
Sample volume	10 to 50 μL per test, depending on assay protocol
Sample probe	Disposable tips for individual sample to avoid carry over; Sample clot detection; Liquid level detection
Sample barcode types	PDF417, Code 128, Codabar (NW 7), Interleaved 2 of 5, Code 39
System interfaces	Touchscreen PC, RS 232 serial interface, bi-directional Standard PC ports (USB, ethernet, serial etc) for other communication devices
Sample database	2,000 results for routine, STAT and controls
Test methods	Pre-defined assay protocols (sandwich, competitive, titration)
Calibration methods	2-point calibration per lot or per cobas e reagent pack
QC methods	Individual QC; Cumulative QC; Preventive QC after calibration
Rerun/repeat/reflex	Rerun, repeat and reflex supported
Electrical requirements	Power requirements: 100–120 VAC 50/60 Hz single phase or 200–240 VAC 50/60 Hz single phase Power consumption: 1,000 VA
Water/waste requirements	Water supply: 3l container Water quality: ≤10μS/cm or ≥0.1 mega Ohm, bacteria-free Liquid waste: 4l container with overflow detection or direct drain Water consumption: Approx. 3l for 250 tests/approx. 12 mL/cycle
Regulatory compliance	GS, CE, UL, C-UL, CB-report and certificate
Operating conditions	Ambient temperature: 8 to 32°C (64.4°F to 89.6°F) Ambient humidity: 20% to 80% Noise output: 60 dbA (stand-by mode), 63 dbA (avg. during operation)
Physical dimensions	Width: 120 to 170 cm (disk/rack) Depth: 73 to 95 cm (disk/rack) Height: 56 cm (w/o PC unit) Weight: Approx. 170 kg (disk) and 210 kg (rack)

 

cobas c 311 assay menu

Substrates	Enzymes	Proteins
Albumin (BCP+BCG)	ACP	a1-Acid Glycoprotein
Ammonia	ALP	a1-Antitrypsin
Bicarbonate	ALT / GPT	a1-Microglobulin
Bilirubin-direct	Amylase-tot.	b2-Microglobulin
Bilirubin-total	Amylase–pancr.	Albumin (immuno.)
Calcium	AST / GOT	APO A1
Cholesterol	Cholinesterase Acetyl	APO B
HDL Cholesterol	Cholinesterase Butyryl	ASLO
LDL Cholesterol	Cholinesterase Dibucain	C3c
Creatinine enz.	CK	C4
Creatinine Jaffé	CK-MB	Ceruloplasmin
Fructosamine	GGT	CRP
Glucose	GLDH	CRP High Sensitivity
Iron	HBDH	Cystatin C
Lactate	LDH	Ferritin
Magnesium	Lipase	Haptoglobin
Phosphorus		HbA1c (whole blood + hemolysate)
Total Protein		Homocysteine 2
Total Protein U / CSF	Electrolytes (ISE)	IgA
Triglycerides	Chloride	IgG
Triglycerides GB	Potassium	IgM
UIBC	Sodium	Kappa Light chains
Urea / BUN		Freelite? Human Lambda Free2
Uric Acid		Lambda Light chains
		Freelite? Human Lambda Free2
		Lipoprotein (a)
		Myoglobin
		Prealbumin
		RF
		Soluble Transferrin Receptor
		Transferrin
Drugs of abuse (DAT)	Therapeutic drug monitoring (TDM)	Others
Amphetamines	Acetaminophen	D-Dimer
Barbiturates	Amikacin	Anti-Thrombin III
Benzodiazepines	Carbamazepine
Cannabinoids	Digitoxin
Cocaine	Digoxin
LSD1	Gentamicin
Ethanol	Lidocaine 1
Methadone	Lithium
Methadone Methabolite (EDDP)	MPA-T
Methaqualone	NAPA
Opiates	Phenobarbital
Oxycodone1	Phenytoin
Phencyclidine	Procainamide
Propoxyphene	Quinidine1
	Salicylate
	Theophylline
	Tobramycin
	Valproic Acid
	Vancomycin

cobas e 411 assay menu

Thyroid function	Tumor markers	Infectious diseases
Anti-TG	AFP	Anti-HAV total
Anti-TPO	CA 125 II	Anti-HAV IgM
Anti-TSHR	CA 15-3	Anti-HBc
Calcitonin1	CA 19-9	Anti-HBc IgM
FT3	CA 72-4	Anti-HBe
FT4	CEA	Anti-HBs
T3	CYFRA 21-1	Anti-HCV
T4	free PSA	HBeAg
T-Uptake	NSE	HBsAg
Tg	total PSA	HBsAg confirmatory
Tg hs1		HBsAg quantification
TSH		CMV lgG
	Cardiac	CMV lgM
	CK-MB (mass)	CMV IgG Avidity 1
Fertility / hormones	CK-MB (mass) STAT	HSV-11
ACTH	Digoxin	HSV-2 1
C peptide	Digitoxin	HIV Antigen
Cortisol	Myoglobin	HIV Antigen confirmatory
DHEA-S	Myoglobin STAT	HIV combi
Estradiol	NT-proBNP	HIV combi PT1
FSH	Troponin T	Rubella IgG
hCG+b	Troponin T hs	Rubella IgM
hCG STAT	Troponin T hs STAT	Toxo IgG
Insulin	Troponin T STAT	Toxo IgM
LH
Progesterone
Prolactin
SHBG
Testosterone
Maternal care	Anemia	Bone markers
free b hCG	Ferritin	b-CrossLaps
PAPP-A	Folate	Vitamin D3 (25-OH)
PlGF	RBC Folate	Intact PTH
sFLT-1	Vitamin B12	N-MID Osteocalcin
		P1NP
		PTH STAT
Rheumatoid Arthritis	Critical care
	IL6
	BRAHMS PCT	Others
	S100	IgE

1 Assays currently under development
2 Partner Channel
Last Update 02/2010

 

好像现在都把日本系列的都给改了一遍，然后把试剂给封闭掉